O365 E5 is the super-powered version of Office and is available for a small increase in cost. In my opinion, the main addition to the E5 license is the fully loaded security features and some analytic tools and voice capabilities. You get everything included in E3 along with a few more benefits:
Other additions include Advance eDiscovery, access controls and control encryption key, Advanced Threat Protection, Threat Intelligence for proactive cybersecurity and actionable insight, O365 Cloud App Security, PTSN conferencing capabilities, Advanced Data Governance and Customer Lockbox.
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